Utilization of thin film method for preparation of celecoxib loaded liposomes

• Main Authors: Eskandar Moghimipour, Somayeh Handali
• Format: Article
• Language: English
• Published: Tabriz University of Medical Sciences 2012-06-01
• Series: Advanced Pharmaceutical Bulletin
• Subjects: Celecoxib; Liposome; Thin film method; Differential scanning calorimeter; Transmission electron microscopy; Particle size
• Online Access: http://apb.tbzmed.ac.ir/Portals/0/Archive/Vol2No1/13.Handali.pdf

Purpose: Celecoxib is nonsteroiddal anti-inflammatory drug that has been used extensively to treat patients with arthritis. The aim of the present study was to formulate and characterize liposomal vesicles loaded with celecoxib. Methods: Liposomes were prepared by thin film method using soya lecithin and cholesterol. The release of drug was determined using a dialysis membrane method. Liposomes were characterized by Differential Scanning Calorimetery (DSC), Transmission Electron Microscopy (TEM) and their particle size was also determined. Results: The results showed that the drug encapsulation efficiency was 67.34% and there was 67.16% release after 0.5, 1, 2, 3, 4, 5, 6, 7, 8 and 24 h. Results of particle size determination showed a mean size of 677nm and nanoparticles were spherical as shown by TEM. The DSC curve of lecithin, cholesterol and celecoxib were different from celecoxib containing liposome. Conclusion: The results of characterization of the vesicles indicated the potential application of celecoxib loaded liposome as carrier system.