Bottom-Up Evolution of Vesicles from Disks to High-Genus Polymersomes

Bottom-Up Evolution of Vesicles from Disks to High-Genus Polymersomes

Summary: Polymersomes are vesicles formed by the self-assembly of amphiphilic copolymers in water. They represent one of the most promising alternatives of natural vesicles as they add new possibilities in the amphiphiles' molecular engineering of aqueous compartments. Here we report the design...

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Main Authors: Claudia Contini, Russell Pearson, Linge Wang, Lea Messager, Jens Gaitzsch, Loris Rizzello, Lorena Ruiz-Perez, Giuseppe Battaglia
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218301305
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spelling doaj-6f7df327f85a409484633b909d0c38cf2020-11-25T00:46:12ZengElsevieriScience2589-00422018-09-017132144Bottom-Up Evolution of Vesicles from Disks to High-Genus PolymersomesClaudia Contini0Russell Pearson1Linge Wang2Lea Messager3Jens Gaitzsch4Loris Rizzello5Lorena Ruiz-Perez6Giuseppe Battaglia7Department of Chemistry, University College London, 20 Gordon Street, Christopher Ingold Building, London WC1H 0AJ, UK; Department of Chemistry, Imperial College London, Imperial College Rd, London SW7 2AZ, UKDepartment of Materials Science and Engineering, University of Sheffield, Broad Lane, Sheffield S3 7HQ, UKDepartment of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK; South China Advanced Institute for Soft Matter Science and Technology, South China University of Technology, Guangzhou 510640, ChinaDepartment of Chemistry, University College London, 20 Gordon Street, Christopher Ingold Building, London WC1H 0AJ, UK; LAGEP, University Claude Bernard Lyon, 43 Boulevard du 11 Novembre 1918, Lyon 69622, FranceDepartment of Chemistry, University College London, 20 Gordon Street, Christopher Ingold Building, London WC1H 0AJ, UK; Department of Chemistry, University of Basel, Mattenstrasse 24a, BPR1096, Basel 4058, SwitzerlandDepartment of Chemistry, University College London, 20 Gordon Street, Christopher Ingold Building, London WC1H 0AJ, UK; Institute of Physics of Living System, University College London, 19 Gordon St, London WC1H 0AH, UKDepartment of Chemistry, University College London, 20 Gordon Street, Christopher Ingold Building, London WC1H 0AJ, UK; EPSRC/Jeol Centre for Liquid Phase Electron Microscopy, University College London, 20 Gordon Street, London WC1H 0AJ, UK; Institute of Physics of Living System, University College London, 19 Gordon St, London WC1H 0AH, UKDepartment of Chemistry, University College London, 20 Gordon Street, Christopher Ingold Building, London WC1H 0AJ, UK; EPSRC/Jeol Centre for Liquid Phase Electron Microscopy, University College London, 20 Gordon Street, London WC1H 0AJ, UK; Institute of Physics of Living System, University College London, 19 Gordon St, London WC1H 0AH, UK; Department of Chemical Engineering, University College London, Torrington Place, London WC1E 6BT, UK; Corresponding authorSummary: Polymersomes are vesicles formed by the self-assembly of amphiphilic copolymers in water. They represent one of the most promising alternatives of natural vesicles as they add new possibilities in the amphiphiles' molecular engineering of aqueous compartments. Here we report the design of polymersomes using a bottom-up approach wherein self-assembly of amphiphilic copolymers poly(2-(methacryloyloxy) ethyl phosphorylcholine)-poly(2-(diisopropylamino) ethyl methacrylate) (PMPC-PDPA) into membranes is tuned using pH and temperature. We report evolution from disk micelles, to vesicles, to high-genus vesicles (vesicles with many holes), where each passage is controlled by pH switch or temperature. We show that the process can be rationalized, adapting membrane physics theories to disclose scaling principles that allow the estimation of minimal radius of vesiculation as well as chain entanglement and coupling. This approach allows us to generate nanoscale vesicles with genus from 0 to 70, which have been very elusive and difficult to control so far. : Polymer Chemistry; Materials Chemistry; Colloids Subject Areas: Polymer Chemistry, Materials Chemistry, Colloidshttp://www.sciencedirect.com/science/article/pii/S2589004218301305
collection DOAJ
language English
format Article
sources DOAJ
author Claudia Contini
Russell Pearson
Linge Wang
Lea Messager
Jens Gaitzsch
Loris Rizzello
Lorena Ruiz-Perez
Giuseppe Battaglia
spellingShingle Claudia Contini
Russell Pearson
Linge Wang
Lea Messager
Jens Gaitzsch
Loris Rizzello
Lorena Ruiz-Perez
Giuseppe Battaglia
Bottom-Up Evolution of Vesicles from Disks to High-Genus Polymersomes
iScience
author_facet Claudia Contini
Russell Pearson
Linge Wang
Lea Messager
Jens Gaitzsch
Loris Rizzello
Lorena Ruiz-Perez
Giuseppe Battaglia
author_sort Claudia Contini
title Bottom-Up Evolution of Vesicles from Disks to High-Genus Polymersomes
title_short Bottom-Up Evolution of Vesicles from Disks to High-Genus Polymersomes
title_full Bottom-Up Evolution of Vesicles from Disks to High-Genus Polymersomes
title_fullStr Bottom-Up Evolution of Vesicles from Disks to High-Genus Polymersomes
title_full_unstemmed Bottom-Up Evolution of Vesicles from Disks to High-Genus Polymersomes
title_sort bottom-up evolution of vesicles from disks to high-genus polymersomes
publisher Elsevier
series iScience
issn 2589-0042
publishDate 2018-09-01
description Summary: Polymersomes are vesicles formed by the self-assembly of amphiphilic copolymers in water. They represent one of the most promising alternatives of natural vesicles as they add new possibilities in the amphiphiles' molecular engineering of aqueous compartments. Here we report the design of polymersomes using a bottom-up approach wherein self-assembly of amphiphilic copolymers poly(2-(methacryloyloxy) ethyl phosphorylcholine)-poly(2-(diisopropylamino) ethyl methacrylate) (PMPC-PDPA) into membranes is tuned using pH and temperature. We report evolution from disk micelles, to vesicles, to high-genus vesicles (vesicles with many holes), where each passage is controlled by pH switch or temperature. We show that the process can be rationalized, adapting membrane physics theories to disclose scaling principles that allow the estimation of minimal radius of vesiculation as well as chain entanglement and coupling. This approach allows us to generate nanoscale vesicles with genus from 0 to 70, which have been very elusive and difficult to control so far. : Polymer Chemistry; Materials Chemistry; Colloids Subject Areas: Polymer Chemistry, Materials Chemistry, Colloids
url http://www.sciencedirect.com/science/article/pii/S2589004218301305
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