Towards Inhibition of Vif-APOBEC3G Interaction: Which Protein to Target?

APOBEC proteins appeared in the cellular battle against HIV-1 as part of intrinsic cellular immunity. The antiretroviral activity of some of these proteins is overtaken by the action of HIV-1 Viral Infectivity Factor (Vif) protein. Since the discovery of APOBEC3G (A3G) as an antiviral factor, many a...

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Bibliographic Details
Main Authors: Iris Cadima-Couto, Joao Goncalves
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Advances in Virology
Online Access:http://dx.doi.org/10.1155/2010/649315