Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons
Amyotrophic lateral sclerosis (ALS) is a devastating, still incurable neurological disorder affecting upper and lower motoneurons. Passive transfer of the disease occurs when immunoglobulins from ALS patients are injected into experimental animals. It is suggested that ALS IgGs cause excitotoxicity...
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University of Belgrade, University of Novi Sad
2007-01-01
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Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2007/0354-46640704251A.pdf |
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doaj-6f78cec6f21a4dcc82cf0afa25a3fc6a2020-11-24T23:07:10ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642007-01-0159425125510.2298/ABS0704251AImmunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneuronsAnđus P.R.Amyotrophic lateral sclerosis (ALS) is a devastating, still incurable neurological disorder affecting upper and lower motoneurons. Passive transfer of the disease occurs when immunoglobulins from ALS patients are injected into experimental animals. It is suggested that ALS IgGs cause excitotoxicity by acting on voltage-gated Ca2+ channels. We reported previously that ALS IgGs increase spontaneous release of glutamate in hippocampal neurons. Since these cells are not normally affected in ALS, we here studied the effect of ALS IgGs on hypoglossal motoneurons in rat brain-stem slices. The frequency of spontaneous glycine-mediated inhibitory postsynaptic currents (sIPSCs) was augmented, but not that of miniature ones (mIPSCs), thus pointing to an indirect effect on release. http://www.doiserbia.nb.rs/img/doi/0354-4664/2007/0354-46640704251A.pdfAmyotrophic lateral sclerosisIgGglycinergic synapsespostsynaptic currentsbrain-stem slicespatch-clamp |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anđus P.R. |
spellingShingle |
Anđus P.R. Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons Archives of Biological Sciences Amyotrophic lateral sclerosis IgG glycinergic synapses postsynaptic currents brain-stem slices patch-clamp |
author_facet |
Anđus P.R. |
author_sort |
Anđus P.R. |
title |
Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons |
title_short |
Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons |
title_full |
Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons |
title_fullStr |
Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons |
title_full_unstemmed |
Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons |
title_sort |
immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons |
publisher |
University of Belgrade, University of Novi Sad |
series |
Archives of Biological Sciences |
issn |
0354-4664 |
publishDate |
2007-01-01 |
description |
Amyotrophic lateral sclerosis (ALS) is a devastating, still incurable neurological disorder affecting upper and lower motoneurons. Passive transfer of the disease occurs when immunoglobulins from ALS patients are injected into experimental animals. It is suggested that ALS IgGs cause excitotoxicity by acting on voltage-gated Ca2+ channels. We reported previously that ALS IgGs increase spontaneous release of glutamate in hippocampal neurons. Since these cells are not normally affected in ALS, we here studied the effect of ALS IgGs on hypoglossal motoneurons in rat brain-stem slices. The frequency of spontaneous glycine-mediated inhibitory postsynaptic currents (sIPSCs) was augmented, but not that of miniature ones (mIPSCs), thus pointing to an indirect effect on release. |
topic |
Amyotrophic lateral sclerosis IgG glycinergic synapses postsynaptic currents brain-stem slices patch-clamp |
url |
http://www.doiserbia.nb.rs/img/doi/0354-4664/2007/0354-46640704251A.pdf |
work_keys_str_mv |
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