Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons

Amyotrophic lateral sclerosis (ALS) is a devastating, still incurable neurological disorder affecting upper and lower motoneurons. Passive transfer of the disease occurs when immunoglobulins from ALS patients are injected into experimental animals. It is suggested that ALS IgGs cause excitotoxicity...

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Main Author: Anđus P.R.
Format: Article
Language:English
Published: University of Belgrade, University of Novi Sad 2007-01-01
Series:Archives of Biological Sciences
Subjects:
IgG
Online Access:http://www.doiserbia.nb.rs/img/doi/0354-4664/2007/0354-46640704251A.pdf
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spelling doaj-6f78cec6f21a4dcc82cf0afa25a3fc6a2020-11-24T23:07:10ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642007-01-0159425125510.2298/ABS0704251AImmunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneuronsAnđus P.R.Amyotrophic lateral sclerosis (ALS) is a devastating, still incurable neurological disorder affecting upper and lower motoneurons. Passive transfer of the disease occurs when immunoglobulins from ALS patients are injected into experimental animals. It is suggested that ALS IgGs cause excitotoxicity by acting on voltage-gated Ca2+ channels. We reported previously that ALS IgGs increase spontaneous release of glutamate in hippocampal neurons. Since these cells are not normally affected in ALS, we here studied the effect of ALS IgGs on hypoglossal motoneurons in rat brain-stem slices. The frequency of spontaneous glycine-mediated inhibitory postsynaptic currents (sIPSCs) was augmented, but not that of miniature ones (mIPSCs), thus pointing to an indirect effect on release. http://www.doiserbia.nb.rs/img/doi/0354-4664/2007/0354-46640704251A.pdfAmyotrophic lateral sclerosisIgGglycinergic synapsespostsynaptic currentsbrain-stem slicespatch-clamp
collection DOAJ
language English
format Article
sources DOAJ
author Anđus P.R.
spellingShingle Anđus P.R.
Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons
Archives of Biological Sciences
Amyotrophic lateral sclerosis
IgG
glycinergic synapses
postsynaptic currents
brain-stem slices
patch-clamp
author_facet Anđus P.R.
author_sort Anđus P.R.
title Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons
title_short Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons
title_full Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons
title_fullStr Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons
title_full_unstemmed Immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons
title_sort immunoglobulins from amyotrophic lateral sclerosis patients enhance the frequency of glycine-mediated spontaneous inhibitory postsynaptic currents in rat hypoglossal motoneurons
publisher University of Belgrade, University of Novi Sad
series Archives of Biological Sciences
issn 0354-4664
publishDate 2007-01-01
description Amyotrophic lateral sclerosis (ALS) is a devastating, still incurable neurological disorder affecting upper and lower motoneurons. Passive transfer of the disease occurs when immunoglobulins from ALS patients are injected into experimental animals. It is suggested that ALS IgGs cause excitotoxicity by acting on voltage-gated Ca2+ channels. We reported previously that ALS IgGs increase spontaneous release of glutamate in hippocampal neurons. Since these cells are not normally affected in ALS, we here studied the effect of ALS IgGs on hypoglossal motoneurons in rat brain-stem slices. The frequency of spontaneous glycine-mediated inhibitory postsynaptic currents (sIPSCs) was augmented, but not that of miniature ones (mIPSCs), thus pointing to an indirect effect on release.
topic Amyotrophic lateral sclerosis
IgG
glycinergic synapses
postsynaptic currents
brain-stem slices
patch-clamp
url http://www.doiserbia.nb.rs/img/doi/0354-4664/2007/0354-46640704251A.pdf
work_keys_str_mv AT anđuspr immunoglobulinsfromamyotrophiclateralsclerosispatientsenhancethefrequencyofglycinemediatedspontaneousinhibitorypostsynapticcurrentsinrathypoglossalmotoneurons
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