Efficacy and Safety of Dual-Drug-Eluting Stents for de Novo Coronary Lesions in South Korea—The Effect Trial

• Main Authors: Jung-Joon Cha, Gi Chang Kim, Seung Ho Hur, Jang Ho Bae, Jae Woong Choi, Dong-Kyu Jin, Seong Il Woo, Seung Uk Lee, Jong Seon Park, Yun-Hyeong Cho, Cheol Ung Choi, Do-Sun Lim, Tae Hoon Ahn
• Format: Article
• Language: English
• Published: MDPI AG 2021-12-01
• Series: Journal of Clinical Medicine
• Subjects: dual drug-eluting stent; Cilotax^™ stent; DXR^™ stent; coronary artery disease; clinical outcome
• Online Access: https://www.mdpi.com/2077-0383/10/1/69

Background: Drug-eluting stents (DESs) are commonly used in percutaneous coronary intervention (PCI) procedures; however, complications including in-stent restenosis and stent thrombosis are significant challenges. The dual-DES is a stent that elutes two drugs to target various stages of the restenosis reaction. This study investigated the safety and efficacy of dual-DES in clinical practice. Methods: This study included 375 patients who underwent PCI with Cilotax^™ or DXR^™ dual-DESs at one of 13 centers in South Korea. The primary endpoint was target lesion failure (TLF) within 1 year. The secondary endpoints were cardiac death, myocardial infarction (MI), target lesion revascularization (TLR), and stent thrombosis. Results: The rates of TLF in dual-DESs (3.7%) were comparable to those reported in conventional DES. In addition, the DXR^™ group had a significantly lower rate of TLF than the Cilotax^™ group. In multivariate analysis, the DXR^™ group had a lower risk of TLF (adjusted hazard ratio (HR) 0.30, 95%CI 0.09–0.92, <i>p</i> = 0.036) and MI (adjusted HR 0.16, 95%CI 0.03–0.82, <i>p</i> = 0.027) than the Cilotax^™ group. Conclusion: Dual-DESs had similar clinical outcomes regarding efficacy and safety as conventional DES. Among the dual-DES, the DXR^™ stent as a new generation dual-DES had more favorable clinical outcomes than the Cilotax^™ stent.