Sestrin2 Regulates Osteoclastogenesis via the p62-TRAF6 Interaction

Sestrin2 Regulates Osteoclastogenesis via the p62-TRAF6 Interaction

The receptor activator of nuclear factor-kappa B ligand (RANKL) mediates osteoclast differentiation and functions by inducing Ca2+ oscillations, activating mitogen-activated protein kinases (MAPKs), and activating nuclear factor of activated T-cells type c1 (NFATc1) via the RANK and tumor necrosis f...

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Bibliographic Details
Main Authors: Sue Young Oh, Namju Kang, Jung Yun Kang, Ki Woo Kim, Jong-Hoon Choi, Yu-Mi Yang, Dong Min Shin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
reactive oxygen species
autophagy inducer
osteoclast differentiation
antioxidant proteins
bone homeostasis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.646803/full

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