A use-dependent increase in release sites drives facilitation at calretinin-deficient cerebellar parallel-fiber synapses

A use-dependent increase in release sites drives facilitation at calretinin-deficient cerebellar parallel-fiber synapses

Endogenous Ca2+-binding proteins affect synaptic transmitter release and short-term plasticity (STP) by buffering presynaptic Ca2+ signals. At parallel-fiber (PF)-to-Purkinje neuron (PN) synapses in the cerebellar cortex loss of calretinin (CR), the major buffer at PF terminals, results in increased...

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Bibliographic Details
Main Authors: Simone eBrachtendorf, Jens eEilers, Hartmut eSchmidt
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
short-term plasticity
calretinin
granule cells
paired recordings
paired-pulse facilitation
Ready-releasable pool
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00027/full

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