Zebularine Promotes Hepatic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells by Interfering with p38 MAPK Signaling

Zebularine Promotes Hepatic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells by Interfering with p38 MAPK Signaling

Demethylating agent zebularine is reported to be capable of inducing differentiation of stem cells by activation of methylated genes, though its function in hepatocyte differentiation is unclear. p38 signal pathway is involved in differentiation of hepatocytes and regulating of DNA methyltransferase...

Full description

Bibliographic Details
Main Authors:	Yong-Heng Luo, Juan Chen, En-Hua Xiao, Qiu-Yun Li, Yong-Mei Luo
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	Stem Cells International
Online Access:	http://dx.doi.org/10.1155/2018/9612512

Similar Items

The regulatory mechanism of p38/MAPK in the chondrogenic differentiation from bone marrow mesenchymal stem cells
by: Ning Ma, et al.
Published: (2019-12-01)

Intermittent Stretching and Osteogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells via the p38MAPK-Osterix Signaling Pathway
by: Wen-lin Xiao, et al.
Published: (2015-06-01)

Comparisons of rabbit bone marrow mesenchymal stem cell isolation and culture methods in vitro.
by: Weidong Zhang, et al.
Published: (2014-01-01)

Behavior and biocompatibility of rabbit bone marrow mesenchymal stem cells with bacterial cellulose membrane
by: Marcello de Alencar Silva, et al.
Published: (2018-04-01)

Protective effect of bone marrow mesenchymal stem cell-derived exosomes against the reproductive toxicity of cyclophosphamide is associated with the p38MAPK/ERK and AKT signaling pathways
by: Xiao-Bin Guo, et al.
Published: (2021-01-01)

Application Progress of Bone Marrow-Derived Mesenchymal Stem Cells in Hepatic Diseases
by: Xiao-hui RAO
Published: (2017-09-01)

Inhibition of hepatic stellate cells by bone marrow-derived mesenchymal stem cells in hepatic fibrosis
by: Yoon Ok Jang, et al.
Published: (2015-06-01)

毩1-antitrypsin combined with bone marrow mesenchymal stem cells regulates retinopathy in diabetic rats via p38 MAPK / NF-κB signaling pathway
by: Hong Chen, et al.
Published: (2021-01-01)

Collagen Peptide Upregulates Osteoblastogenesis from Bone Marrow Mesenchymal Stem Cells through MAPK- Runx2
by: Jeevithan Elango, et al.
Published: (2019-05-01)

Effect of Warm Acupuncture Combined with Bone Marrow Mesenchymal Stem Cells Transplantation on Cartilage Tissue in Rabbit Knee Osteoarthritis
by: Jun-wei Liu, et al.
Published: (2021-01-01)

Tracking Bone Marrow Mesenchymal Stem Cells Transplanted to Experimental Rabbit Model with Brain Trauma by MRI
by: Ayoob Rostamzadeh, et al.
Published: (2014-05-01)

Different media and supplements modulate the clonogenic and expansion properties of rabbit bone marrow mesenchymal stem cells
by: Vanacore Renato, et al.
Published: (2008-07-01)

Low magnitude high frequency vibration promotes adipogenic differentiation of bone marrow stem cells via P38 MAPK signal.
by: Qian Zhao, et al.
Published: (2017-01-01)

Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells.
by: Irina A Potapova, et al.
Published: (2013-01-01)

Hepatitis B virus infection and replication in human bone marrow mesenchymal stem cells
by: Ma Ruiping, et al.
Published: (2011-10-01)

High Variability in Rabbit Bone Marrow-Derived Mesenchymal Cell Preparations
by: Luis A. Solchaga, et al.
Published: (1999-09-01)

Effect of Dextromethorphan on Adipogenic Differentiation in Rat Bone Marrow-Derived Mesenchymal Stem Cells
by: LUO, YU-PO, et al.
Published: (2017)

Bone Marrow Mesenchymal Stem Cells Expressing Baculovirus-Engineered Bone Morphogenetic Protein-7 Enhance Rabbit Posterolateral Fusion
by: Jen-Chung Liao
Published: (2016-07-01)

Effect of neuroglobin genetically modified bone marrow mesenchymal stem cells transplantation on spinal cord injury in rabbits.
by: Wen-Ping Lin, et al.
Published: (2013-01-01)

Autologous bone-marrow mesenchymal stem cell implantation and endothelial function in a rabbit ischemic limb model.
by: Shinsuke Mikami, et al.
Published: (2013-01-01)

The experimental research on the treatment of rabbits with acute cornea alkali burn by taking bone marrow mesenchymal stem cell
by: Zhou Yin
Published: (2018-01-01)

Effect of Activated Platelet-Rich Plasma on Chondrogenic Differentiation of Rabbit Bone Marrow-Derived Mesenchymal Stem Cells
by: Zhen Wang, et al.
Published: (2021-01-01)

DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis.
by: Kazuaki Nakamura, et al.
Published: (2013-01-01)

Investigation of Zebularine-induced Cell Cycle Arrest and Apoptosis
by: Shan-Hu Lin, et al.
Published: (2008)

Correction: Low magnitude high frequency vibration promotes adipogenic differentiation of bone marrow stem cells via P38 MAPK signal.
by: Qian Zhao, et al.
Published: (2017-01-01)

Directional homing of glycosylation-modified bone marrow mesenchymal stem cells for bone defect repair
by: Long Chen, et al.
Published: (2021-07-01)

Modification of histone acetylation facilitates hepatic differentiation of human bone marrow mesenchymal stem cells.
by: Xuejun Dong, et al.
Published: (2013-01-01)

Correction: Hepatitis B virus infection and replication in human bone marrow mesenchymal stem cells
by: Ma Ruiping, et al.
Published: (2012-05-01)

Human bone marrow-derived mesenchymal stem cells
by: Lopez M, et al.
Published: (2007-01-01)

Isolation, expansion and differentiation of mesenchymal stromal cells from rabbits' bone marrow
by: Renato B. Eleotério, et al.
Published: (2016-05-01)

Expression of chemokine receptor-4 in bone marrow mesenchymal stem cells on experimental rat abdominal aortic aneurysms and the migration of bone marrow mesenchymal stem cells with stromal-derived factor-1
by: Miao-Yun Long, et al.
Published: (2014-05-01)

Glutamine Metabolism Is Essential for Stemness of Bone Marrow Mesenchymal Stem Cells and Bone Homeostasis
by: Tao Zhou, et al.
Published: (2019-01-01)

Comparing the Osteogenic Potentials and Bone Regeneration Capacities of Bone Marrow and Dental Pulp Mesenchymal Stem Cells in a Rabbit Calvarial Bone Defect Model
by: Yu-Chieh Lee, et al.
Published: (2019-10-01)

Distinct Responses of Arabidopsis Telomeres and Transposable Elements to Zebularine Exposure
by: Klára Konečná, et al.
Published: (2021-01-01)

Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine.
by: Christine Champion, et al.
Published: (2010-08-01)

iRoot BP Plus promotes osteo/odontogenic differentiation of bone marrow mesenchymal stem cells via MAPK pathways and autophagy
by: Jiamin Lu, et al.
Published: (2019-07-01)

Promotion of Hepatic Differentiation of Bone Marrow Mesenchymal Stem Cells on Decellularized Cell-Deposited Extracellular Matrix
by: Hongliang He, et al.
Published: (2013-01-01)

Effect of inorganic phosphate on migration and osteogenic differentiation of bone marrow mesenchymal stem cells
by: Hengzhang Lin, et al.
Published: (2021-01-01)

Role of FGF-2 Transfected Bone Marrow Mesenchymal Stem Cells in Engineered Bone Tissue for Repair of Avascular Necrosis of Femoral Head in Rabbits
by: Fei Zhang, et al.
Published: (2018-07-01)

Cellular Heterogeneity of Mesenchymal Stem/Stromal Cells in the Bone Marrow
by: Yo Mabuchi, et al.
Published: (2021-07-01)