High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes

High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes

Fibroblast activation protein α (FAP) plays an important role in tissue remodeling and helps tumor cells invade surrounding tissue. We sought to investigate FAP as a prognostic molecular marker in colorectal cancer (CRC) using immunohistochemical and transcriptomic data. FAP expression and clinicopa...

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Bibliographic Details
Main Authors: Mairene Coto-Llerena, Caner Ercan, Venkatesh Kancherla, Stephanie Taha-Mehlitz, Serenella Eppenberger-Castori, Savas D. Soysal, Charlotte K. Y. Ng, Martin Bolli, Markus von Flüe, Guillaume P. Nicolas, Luigi M. Terracciano, Melpomeni Fani, Salvatore Piscuoglio
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
cancer-associated fibroblast
immunohistochemistry
FAP
gene expression
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00979/full

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