Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells.

Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells.

Reduced DNA methylation has been reported in DICER1-deficient mouse ES cells. Reductions seen at pericentric satellite repeats have suggested that siRNAs are required for the proper assembly of heterochromatin. More recent studies have postulated that the reduced methylation is an indirect effect: t...

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Bibliographic Details
Main Authors: Jonathan Ip, Paul Canham, K H Andy Choo, Yoshimi Inaba, Shelley A Jacobs, Paul Kalitsis, Deidre M Mattiske, Jane Ng, Richard Saffery, Nicholas C Wong, Lee H Wong, Jeffrey R Mann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3435250?pdf=render

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http://europepmc.org/articles/PMC3435250?pdf=render

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