Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa.

Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa.

South Africa shows one of the highest global burdens of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). Since 2002, MDR-TB in South Africa has been treated by a standardized combination therapy, which until 2010 included ofloxacin, kanamycin, ethionamide, ethambutol...

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Main Authors: Borna Müller, Violet N Chihota, Manormoney Pillay, Marisa Klopper, Elizabeth M Streicher, Gerrit Coetzee, Andre Trollip, Cindy Hayes, Marlein E Bosman, Nicolaas C Gey van Pittius, Thomas C Victor, Sebastien Gagneux, Paul D van Helden, Robin M Warren
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3751934?pdf=render

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