Time-dependent modulation of FoxO activity by HDAC inhibitor in oncogene-transformed E1A+Ras cells

Time-dependent modulation of FoxO activity by HDAC inhibitor in oncogene-transformed E1A+Ras cells

HDAC inhibitors (HDACIs) induce irreversible cell cycle arrest and senescence in mouse embryonic fibroblasts transformed with E1A and c-Ha-Ras oncogenes (E1A+Ras cell line). The aging rate has been associated with the production of high levels of Reactive Oxygen Species (ROS). Specific increases of...

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Bibliographic Details
Main Authors: Alisa Morshneva, Olga Gnedina, Svetlana Svetlikova, Valery Pospelov, Maria Igotti
Format: Article
Language:English
Published: AIMS Press 2018-02-01
Series:AIMS Genetics
Subjects:
histone deacetylase inhibitor (HDACi)
sodium butyrate
FoxO
oxidative stress
ROS
Akt
nuclear shuttling
Online Access:http://www.aimspress.com/Genetics/article/1825/fulltext.html

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