Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology

• Main Authors: Anqi Zhou, Hui Yu, Jiayi Liu, Jianan Zheng, Yinan Jia, Bingfeng Wu, Lin Xiang
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2020-08-01
• Series: Frontiers in Cell and Developmental Biology
• Subjects: osseointegration; Hippo-YAP; osteogenesis; angiogenesis; osteoimmunology; bone remodeling
• Online Access: https://www.frontiersin.org/article/10.3389/fcell.2020.00780/full

The social demand for dental implantation is growing at a rapid rate, while dentists are faced with the dilemma of implantation failures associated with unfavorable osseointegration. Clinical-friendly osteogenesis, angiogenesis and osteoimmunology around dental implants play a pivotal role in a desirable osseointegration and it’s increasingly appreciated that Hippo-YAP signaling pathway is implicated in those biological processes both in vitro and in vivo in a variety of study. In this article we review the multiple effects of Hippo-YAP signaling in osseointegration of dental implants by regulating osteogenesis, angiogenesis and osteoimmunology in peri-implant tissue, as well as highlight prospective future directions of relevant investigation.