Chemo-Electrical Signal Transduction by Using Stimuli-Responsive Polymer Gate-Modified Field Effect Transistor

Chemo-Electrical Signal Transduction by Using Stimuli-Responsive Polymer Gate-Modified Field Effect Transistor

A glucose-responsive polymer brush was designed on a gold electrode and exploited as an extended gate for a field effect transistor (FET) based biosensor. A permittivity change at the gate interface due to the change in hydration upon specific binding with glucose was detectable. The rate of respons...

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Main Authors: Akira Matsumoto, Yusuke Tsurui, Hiroko Matsumoto, Yasuhiro Maeda, Toru Hoshi, Takashi Sawaguchi, Yuji Miyahara
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Chemosensors
Subjects:
field effect transistors
permittivity
Debye length
stimuli-responsive polymers
Online Access:http://www.mdpi.com/2227-9040/2/2/97
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spelling doaj-6f3e28ac3b4241858d4608d52154baab2020-11-25T02:17:15ZengMDPI AGChemosensors2227-90402014-03-01229710710.3390/chemosensors2020097chemosensors2020097Chemo-Electrical Signal Transduction by Using Stimuli-Responsive Polymer Gate-Modified Field Effect TransistorAkira Matsumoto0Yusuke Tsurui1Hiroko Matsumoto2Yasuhiro Maeda3Toru Hoshi4Takashi Sawaguchi5Yuji Miyahara6Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308, JapanInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308, JapanDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308, JapanInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanA glucose-responsive polymer brush was designed on a gold electrode and exploited as an extended gate for a field effect transistor (FET) based biosensor. A permittivity change at the gate interface due to the change in hydration upon specific binding with glucose was detectable. The rate of response was markedly enhanced compared to the previously studied cross-linked or gel-coupled electrode, owing to its kinetics involving no process of the polymer network diffusion. This finding may offer a new strategy of the FET-based biosensors effective not only for large molecules but also for electrically neutral molecules such as glucose with improved kinetics.http://www.mdpi.com/2227-9040/2/2/97field effect transistorspermittivityDebye lengthstimuli-responsive polymers
collection DOAJ
language English
format Article
sources DOAJ
author Akira Matsumoto
Yusuke Tsurui
Hiroko Matsumoto
Yasuhiro Maeda
Toru Hoshi
Takashi Sawaguchi
Yuji Miyahara
spellingShingle Akira Matsumoto
Yusuke Tsurui
Hiroko Matsumoto
Yasuhiro Maeda
Toru Hoshi
Takashi Sawaguchi
Yuji Miyahara
Chemo-Electrical Signal Transduction by Using Stimuli-Responsive Polymer Gate-Modified Field Effect Transistor
Chemosensors
field effect transistors
permittivity
Debye length
stimuli-responsive polymers
author_facet Akira Matsumoto
Yusuke Tsurui
Hiroko Matsumoto
Yasuhiro Maeda
Toru Hoshi
Takashi Sawaguchi
Yuji Miyahara
author_sort Akira Matsumoto
title Chemo-Electrical Signal Transduction by Using Stimuli-Responsive Polymer Gate-Modified Field Effect Transistor
title_short Chemo-Electrical Signal Transduction by Using Stimuli-Responsive Polymer Gate-Modified Field Effect Transistor
title_full Chemo-Electrical Signal Transduction by Using Stimuli-Responsive Polymer Gate-Modified Field Effect Transistor
title_fullStr Chemo-Electrical Signal Transduction by Using Stimuli-Responsive Polymer Gate-Modified Field Effect Transistor
title_full_unstemmed Chemo-Electrical Signal Transduction by Using Stimuli-Responsive Polymer Gate-Modified Field Effect Transistor
title_sort chemo-electrical signal transduction by using stimuli-responsive polymer gate-modified field effect transistor
publisher MDPI AG
series Chemosensors
issn 2227-9040
publishDate 2014-03-01
description A glucose-responsive polymer brush was designed on a gold electrode and exploited as an extended gate for a field effect transistor (FET) based biosensor. A permittivity change at the gate interface due to the change in hydration upon specific binding with glucose was detectable. The rate of response was markedly enhanced compared to the previously studied cross-linked or gel-coupled electrode, owing to its kinetics involving no process of the polymer network diffusion. This finding may offer a new strategy of the FET-based biosensors effective not only for large molecules but also for electrically neutral molecules such as glucose with improved kinetics.
topic field effect transistors
permittivity
Debye length
stimuli-responsive polymers
url http://www.mdpi.com/2227-9040/2/2/97
work_keys_str_mv AT akiramatsumoto chemoelectricalsignaltransductionbyusingstimuliresponsivepolymergatemodifiedfieldeffecttransistor
AT yusuketsurui chemoelectricalsignaltransductionbyusingstimuliresponsivepolymergatemodifiedfieldeffecttransistor
AT hirokomatsumoto chemoelectricalsignaltransductionbyusingstimuliresponsivepolymergatemodifiedfieldeffecttransistor
AT yasuhiromaeda chemoelectricalsignaltransductionbyusingstimuliresponsivepolymergatemodifiedfieldeffecttransistor
AT toruhoshi chemoelectricalsignaltransductionbyusingstimuliresponsivepolymergatemodifiedfieldeffecttransistor
AT takashisawaguchi chemoelectricalsignaltransductionbyusingstimuliresponsivepolymergatemodifiedfieldeffecttransistor
AT yujimiyahara chemoelectricalsignaltransductionbyusingstimuliresponsivepolymergatemodifiedfieldeffecttransistor
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