Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk

Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk

Numerous viruses have evolved sophisticated countermeasures to hijack the early programmed cell death of host cells in response to infection, including the use of proteins homologous in sequence or structure to Bcl-2. Orf virus, a member of the <i>parapoxviridae</i>, encodes for the Bcl-...

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Bibliographic Details
Main Authors: Chathura D. Suraweera, Mark G. Hinds, Marc Kvansakul
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Viruses
Subjects:
poxvirus
orf virus
apoptosis
Bcl-2 proteins
X-ray crystallography
Online Access:https://www.mdpi.com/1999-4915/13/7/1374

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