Spreading depolarization evoked by endothelin-1 is inhibited by octanol but not by carbenoxolone

Spreading depolarization (SD) has been implicated in the pathogenesis of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage. Endothelin-1 (ET-1) is a powerful trigger of SD and may be involved in DCI. The SD-causing mechanism is assumed to result from ET-1-induced microarterial spasm and...

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Bibliographic Details
Main Authors: Gabor C. Petzold, Jens P. Dreier
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-03-01
Series:Brain Hemorrhages
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589238X20300425