N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization

NF-κB signalling is critical to TLR mediated cytokine release in various immune responses. Here the authors show how N4BP1 inhibits NEMO signalling and subsequent NF-κB activation and how this pathway is negatively regulated by caspase-8 cleavage of N4BP1.

Bibliographic Details
Main Authors:	Hexin Shi, Lei Sun, Ying Wang, Aijie Liu, Xiaoming Zhan, Xiaohong Li, Miao Tang, Priscilla Anderton, Sara Hildebrand, Jiexia Quan, Sara Ludwig, Eva Marie Y. Moresco, Bruce Beutler
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-21711-5

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spelling	doaj-6f2f436288994d16853156c62b5e290b2021-03-11T11:31:06ZengNature Publishing GroupNature Communications2041-17232021-03-0112111210.1038/s41467-021-21711-5N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerizationHexin Shi0Lei Sun1Ying Wang2Aijie Liu3Xiaoming Zhan4Xiaohong Li5Miao Tang6Priscilla Anderton7Sara Hildebrand8Jiexia Quan9Sara Ludwig10Eva Marie Y. Moresco11Bruce Beutler12Center for the Genetics of Host Defense, University of Texas Southwestern Medical CenterCenter for the Genetics of Host Defense, University of Texas Southwestern Medical CenterCenter for the Genetics of Host Defense, University of Texas Southwestern Medical CenterCenter for the Genetics of Host Defense, University of Texas Southwestern Medical CenterCenter for the Genetics of Host Defense, University of Texas Southwestern Medical CenterCenter for the Genetics of Host Defense, University of Texas Southwestern Medical CenterCenter for the Genetics of Host Defense, University of Texas Southwestern Medical CenterCenter for the Genetics of Host Defense, University of Texas Southwestern Medical CenterCenter for the Genetics of Host Defense, University of Texas Southwestern Medical CenterCenter for the Genetics of Host Defense, University of Texas Southwestern Medical CenterCenter for the Genetics of Host Defense, University of Texas Southwestern Medical CenterCenter for the Genetics of Host Defense, University of Texas Southwestern Medical CenterCenter for the Genetics of Host Defense, University of Texas Southwestern Medical CenterNF-κB signalling is critical to TLR mediated cytokine release in various immune responses. Here the authors show how N4BP1 inhibits NEMO signalling and subsequent NF-κB activation and how this pathway is negatively regulated by caspase-8 cleavage of N4BP1.https://doi.org/10.1038/s41467-021-21711-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hexin Shi Lei Sun Ying Wang Aijie Liu Xiaoming Zhan Xiaohong Li Miao Tang Priscilla Anderton Sara Hildebrand Jiexia Quan Sara Ludwig Eva Marie Y. Moresco Bruce Beutler
spellingShingle	Hexin Shi Lei Sun Ying Wang Aijie Liu Xiaoming Zhan Xiaohong Li Miao Tang Priscilla Anderton Sara Hildebrand Jiexia Quan Sara Ludwig Eva Marie Y. Moresco Bruce Beutler N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization Nature Communications
author_facet	Hexin Shi Lei Sun Ying Wang Aijie Liu Xiaoming Zhan Xiaohong Li Miao Tang Priscilla Anderton Sara Hildebrand Jiexia Quan Sara Ludwig Eva Marie Y. Moresco Bruce Beutler
author_sort	Hexin Shi
title	N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
title_short	N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
title_full	N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
title_fullStr	N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
title_full_unstemmed	N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
title_sort	n4bp1 negatively regulates nf-κb by binding and inhibiting nemo oligomerization
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-03-01
description	NF-κB signalling is critical to TLR mediated cytokine release in various immune responses. Here the authors show how N4BP1 inhibits NEMO signalling and subsequent NF-κB activation and how this pathway is negatively regulated by caspase-8 cleavage of N4BP1.
url	https://doi.org/10.1038/s41467-021-21711-5
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N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization

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