N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
NF-κB signalling is critical to TLR mediated cytokine release in various immune responses. Here the authors show how N4BP1 inhibits NEMO signalling and subsequent NF-κB activation and how this pathway is negatively regulated by caspase-8 cleavage of N4BP1.
Bibliographic Details
| Main Authors: |
Hexin Shi,
Lei Sun,
Ying Wang,
Aijie Liu,
Xiaoming Zhan,
Xiaohong Li,
Miao Tang,
Priscilla Anderton,
Sara Hildebrand,
Jiexia Quan,
Sara Ludwig,
Eva Marie Y. Moresco,
Bruce Beutler |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-21711-5
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