Involvements of p38 MAPK and oxidative stress in the ozone-induced enhancement of AHR and pulmonary inflammation in an allergic asthma model

Involvements of p38 MAPK and oxidative stress in the ozone-induced enhancement of AHR and pulmonary inflammation in an allergic asthma model

Abstract Background Exposure to ambient ozone (O3) increases the susceptivity to allergens and triggers exacerbations in patients with asthma. However, the detailed mechanisms of action for O3 to trigger asthma exacerbations are still unclear. Methods An ovalbumin (OVA)-established asthmatic mouse m...

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Bibliographic Details
Main Authors: Aihua Bao, Hong Yang, Jie Ji, Yuqin Chen, Wuping Bao, Feng Li, Min Zhang, Xin Zhou, Qiang Li, Suqin Ben
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Respiratory Research
Subjects:
Asthma exacerbation
Ozone
p38 MAPK
Oxidative stress
α-tocopherol
Online Access:http://link.springer.com/article/10.1186/s12931-017-0697-4

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http://link.springer.com/article/10.1186/s12931-017-0697-4

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