Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

All metazoans that utilize molecular oxygen (O<sub>2</sub>) for metabolic purposes have the capacity to adapt to hypoxia, the condition that arises when O<sub>2</sub> demand exceeds supply. This is mediated through activation of the hypoxia-inducible factor (HIF) pathway. At...

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Bibliographic Details
Main Authors:	Moritz J. Strowitzki, Eoin P. Cummins, Cormac T. Taylor
Format:	Article
Language:	English
Published:	MDPI AG 2019-04-01
Series:	Cells
Subjects:	hypoxia prolyl hydroxylation hypoxia-inducible factor mass spectrometry HIF-prolyl hydroxylases factor inhibiting HIF Cep192 IKK-β p105 p53 FOXO3a OTUB1 MAPK6 RIPK4
Online Access:	https://www.mdpi.com/2073-4409/8/5/384

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