Assessment of SLX4 Mutations in Hereditary Breast Cancers.

Assessment of SLX4 Mutations in Hereditary Breast Cancers.

<label>BACKGROUND</label>SLX4 encodes a DNA repair protein that regulates three structure-specific endonucleases and is necessary for resistance to DNA crosslinking agents, topoisomerase I and poly (ADP-ribose) polymerase (PARP) inhibitors. Recent studies have reported mutations in SLX4...

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Main Authors: Sohela Shah, Yonghwan Kim, Irina Ostrovnaya, Rajmohan Murali, Kasmintan A Schrader, Francis P Lach, Kara Sarrel, Rohini Rau-Murthy, Nichole Hansen, Liyng Zhang, Tomas Kirchhoff, Zsofia Stadler, Mark Robson, Joseph Vijai, Kenneth Offit, Agata Smogorzewska
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3694110?pdf=render

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