IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release

IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release

The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine releas...

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Main Authors: U. Westin, E. Lundberg, K. Ohlsson
Format: Article
Language:English
Published: Hindawi Limited 1998-01-01
Series:Mediators of Inflammation
Subjects:
SLPI
IgE
chymase
histamine
nasal mucosa.
Online Access:http://dx.doi.org/10.1080/09629359891162
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spelling doaj-6f13f03a40364647a25a138903ffc1892020-11-25T01:04:42ZengHindawi LimitedMediators of Inflammation0962-93511466-18611998-01-017321722010.1080/09629359891162IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous releaseU. Westin0E. Lundberg1K. Ohlsson2Department of Otolaryngology and Head and Neck Surgery, University Hospital of Malmö, University of Lund, Malmö SE-205 02, SwedenDepartment of Surgical Pathophysiology, University Hospital of Malmö, University of Lund, Malmö SE-205 02, SwedenDepartment of Surgical Pathophysiology, University Hospital of Malmö, University of Lund, Malmö SE-205 02, SwedenThe secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.http://dx.doi.org/10.1080/09629359891162SLPIIgEchymasehistaminenasal mucosa.
collection DOAJ
language English
format Article
sources DOAJ
author U. Westin
E. Lundberg
K. Ohlsson
spellingShingle U. Westin
E. Lundberg
K. Ohlsson
IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release
Mediators of Inflammation
SLPI
IgE
chymase
histamine
nasal mucosa.
author_facet U. Westin
E. Lundberg
K. Ohlsson
author_sort U. Westin
title IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release
title_short IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release
title_full IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release
title_fullStr IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release
title_full_unstemmed IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release
title_sort ige-mediated histamine release from nasal mucosa is inhibited by slpi (secretory leukocyte protease inhibitor) to the level of spontaneous release
publisher Hindawi Limited
series Mediators of Inflammation
issn 0962-9351
1466-1861
publishDate 1998-01-01
description The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.
topic SLPI
IgE
chymase
histamine
nasal mucosa.
url http://dx.doi.org/10.1080/09629359891162
work_keys_str_mv AT uwestin igemediatedhistaminereleasefromnasalmucosaisinhibitedbyslpisecretoryleukocyteproteaseinhibitortothelevelofspontaneousrelease
AT elundberg igemediatedhistaminereleasefromnasalmucosaisinhibitedbyslpisecretoryleukocyteproteaseinhibitortothelevelofspontaneousrelease
AT kohlsson igemediatedhistaminereleasefromnasalmucosaisinhibitedbyslpisecretoryleukocyteproteaseinhibitortothelevelofspontaneousrelease
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