| Summary: | Background: There are only very few studies which compared 25 and 50 microgram of misoprostol in relation to neonatal outcome and Indian data in this context are lacking.
Methods: This study was carried out as a single centre, prospective, observational study which consisted of 100 term pregnant women divided in two groups. Neonatal outcome was compared in relation to frequency of abnormalfetal heart rate tracings, meconium passage, 1- or 5-minute Apgar scores < 7, neonatal resuscitations, or admissions to the neonatal intensive care unit
Result: Meconium stained liquor was observed in 6% of cases in both groups. Apgar score at 1 min was <7 in 10% of cases in 25 meg group against 6% in 50 meg group. Requirement of neonatal resuscitation was observed in 10% of cases in each group. Fetal heart rate abnormality was observed in 22% of cases in 50 meg group against 12% in 25 meg group. Neonatal problems were detected in 14% and 12% of cases in 25 meg and 50 meg group respectively. Statistically these difference were not significant
Conclusion: There is no significant difference in neonatal outcome with 25 and 50 microgram of misoprostol used for induction of delivery in term pregnancy.
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