Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations

Debranching of glycogen is an important step in its use as an energy source. Here, the authors describe the crystal structures of glycogen debranching enzyme alone and in complex with oligosaccharides and provide molecular insights into the function, and into associated diseases.

Bibliographic Details
Main Authors:	Liting Zhai, Lingling Feng, Lin Xia, Huiyong Yin, Song Xiang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms11229

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spelling	doaj-6f02788bb1894b07b2fa0be196a975052021-05-11T11:13:56ZengNature Publishing GroupNature Communications2041-17232016-04-017111110.1038/ncomms11229Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutationsLiting Zhai0Lingling Feng1Lin Xia2Huiyong Yin3Song Xiang4Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesDebranching of glycogen is an important step in its use as an energy source. Here, the authors describe the crystal structures of glycogen debranching enzyme alone and in complex with oligosaccharides and provide molecular insights into the function, and into associated diseases.https://doi.org/10.1038/ncomms11229
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Liting Zhai Lingling Feng Lin Xia Huiyong Yin Song Xiang
spellingShingle	Liting Zhai Lingling Feng Lin Xia Huiyong Yin Song Xiang Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations Nature Communications
author_facet	Liting Zhai Lingling Feng Lin Xia Huiyong Yin Song Xiang
author_sort	Liting Zhai
title	Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations
title_short	Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations
title_full	Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations
title_fullStr	Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations
title_full_unstemmed	Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations
title_sort	crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-04-01
description	Debranching of glycogen is an important step in its use as an energy source. Here, the authors describe the crystal structures of glycogen debranching enzyme alone and in complex with oligosaccharides and provide molecular insights into the function, and into associated diseases.
url	https://doi.org/10.1038/ncomms11229
work_keys_str_mv	AT litingzhai crystalstructureofglycogendebranchingenzymeandinsightsintoitscatalysisanddiseasecausingmutations AT linglingfeng crystalstructureofglycogendebranchingenzymeandinsightsintoitscatalysisanddiseasecausingmutations AT linxia crystalstructureofglycogendebranchingenzymeandinsightsintoitscatalysisanddiseasecausingmutations AT huiyongyin crystalstructureofglycogendebranchingenzymeandinsightsintoitscatalysisanddiseasecausingmutations AT songxiang crystalstructureofglycogendebranchingenzymeandinsightsintoitscatalysisanddiseasecausingmutations
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Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations

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