Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers

Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers

There is a pressing need for molecular targets and biomarkers in gastric cancer (GC). We aimed at identifying aberrations in L-arginine metabolism with therapeutic and diagnostic potential. Systemic metabolites were quantified using mass spectrometry in 293 individuals and enzymes’ gene expression w...

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Bibliographic Details
Main Authors:	Iwona Bednarz-Misa, Mariusz G. Fleszar, Paulina Fortuna, Łukasz Lewandowski, Magdalena Mierzchała-Pasierb, Dorota Diakowska, Małgorzata Krzystek-Korpacka
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	Biomolecules
Subjects:	metabolic reprogramming arginine auxotrophy argininosuccinate lyase dimethylarginine dimethylaminohydrolase protein arginine methyltransferase nitric oxide synthase
Online Access:	https://www.mdpi.com/2218-273X/11/8/1086

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