Combining DNA Damage Induction with BCL-2 Inhibition to Enhance Merkel Cell Carcinoma Cytotoxicity

Combining DNA Damage Induction with BCL-2 Inhibition to Enhance Merkel Cell Carcinoma Cytotoxicity

Merkel cell carcinoma (MCC) is a highly lethal skin cancer. MCC tumors rapidly develop resistance to the chemotherapies tested to date. While PD-1/PD-L1 immune checkpoint blockade has demonstrated success in MCC treatment, a significant portion of MCC patients are nonresponsive. Therefore, the press...

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Bibliographic Details
Main Authors:	Wei Liu, Nathan A. Krump, Meenhard Herlyn, Jianxin You
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Biology
Subjects:	merkel cell carcinoma dna damage induction bcl2 inhibitor abt-199
Online Access:	https://www.mdpi.com/2079-7737/9/2/35

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