Abnormal T-Cell Development in the Thymus of Non-obese Diabetic Mice: Possible Relationship With the Pathogenesis of Type 1 Autoimmune Diabetes

Abnormal T-Cell Development in the Thymus of Non-obese Diabetic Mice: Possible Relationship With the Pathogenesis of Type 1 Autoimmune Diabetes

Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-producing cells in the pancreas, by direct interactions with autoreactive pancreas infiltrating T lymphocytes (PILs). One of the most important animal models for this disease is the non-obese diabetic (NOD) mouse. Al...

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Bibliographic Details
Main Authors: Daniella A. Mendes-da-Cruz, Julia P. Lemos, Geraldo A. Passos, Wilson Savino
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Endocrinology
Subjects:
non-obese diabetic mouse
type 1 diabetes
thymus
autoimmune diabetes
insulin
insulin-like growth factor
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00381/full

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