A Single Microorganism Epitope Attenuates the Development of Murine Autoimmune Arthritis: Regulation of Dendritic Cells via the Mannose Receptor

A Single Microorganism Epitope Attenuates the Development of Murine Autoimmune Arthritis: Regulation of Dendritic Cells via the Mannose Receptor

A single epitope of Leishmania analog of the receptors for activated C kinase (LACK) from Leishmania major, the polypeptide LACK156–173, is recognized by Vβ4+/Vα8+ T cells, and activate these cells that drives the subsequent T helper (Th)2 response. This study was undertaken to investigate the thera...

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Bibliographic Details
Main Authors: Fan Yang, Xuemei Fan, He Huang, Qiujie Dang, Hongwei Lei, Yang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
arthritis
Leishmania major
dendritic cells
Jagged1
mannose receptor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01528/full

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