Preparation and application prospects metal containing biocorrectors as part of film coverings to maintain human health

• Main Authors: L. P. Lazurina, Y. V. Tikhonova, D. A. Alieva, L. V. Antipova
• Format: Article
• Language: Russian
• Published: Voronezh state university of engineering technologies 2016-07-01
• Series: Vestnik Voronežskogo Gosudarstvennogo Universiteta Inženernyh Tehnologij
• Subjects: micronutrients; copper; chelates; biocorrectors; vitamins
• Online Access: https://www.vestnik-vsuet.ru/vguit/article/view/931

The study of mixed-ligand complex formation is important problem of coordination chemistry currently. The ligands of different nature within the domestic environment of the complex, have a mutual influence, changing the chemical properties of complexes (acid-base, oxidation-reduction, the rate of ligand substitution in the internal environment) and their biological activity. According to the literature, the issues of mutual influence of ligands, which leads to a change in the reactivity of the complexes have been widely studied with the assistance of ligands of different nature. In recent years sharply increased interest in nanoobjects of different nature. This is due to the fact that many of the physical, chemical and biological properties of the nanoparticles significantly different characteristics from those of larger (macroscopic) objects. The aim of the study was to examine the conditions of formation (ratio of components, acidity) in solutions of mixed-metal biocomplexes copper. The studies have shown that the conditions of synthesis have significant impact on obtaining nanoparticles of zinc, copper and cobalt. The study of morphology and size of the resulting nanoparticles were performed on a scanning electron microscope Quanta FEG 650 in high vacuum (pressure in the chamber 8⋅10-3 to 3⋅10-3 Pa) mode. The resulting nanoparticles are studied metal particles kanglomeraty complex structure of various shapes and sizes up to 200 nm, and the crystals are spherical shape sizes of 40–90 nm. It is shown that metal complexation with drugs (ligands) leads to improvement of antimicrobial activity spectrum and expansion relative to the parent ligands, the studied biocomplexes are harmless biologically active substances, which can be recommended for further study.