Intravenous glial growth factor 2 (GGF2) isoform of neuregulin-1β improves left ventricular function, gene and protein expression in rats after myocardial infarction.

Intravenous glial growth factor 2 (GGF2) isoform of neuregulin-1β improves left ventricular function, gene and protein expression in rats after myocardial infarction.

Recombinant Neuregulin (NRG)-1β has multiple beneficial effects on cardiac myocytes in culture, and has potential as a clinical therapy for heart failure (HF). A number of factors may influence the effect of NRG-1β on cardiac function via ErbB receptor coupling and expression. We examined the effect...

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Main Authors: Michael F Hill, Amish V Patel, Abigail Murphy, Holly M Smith, Cristi L Galindo, Laura Pentassuglia, Xuyang Peng, Carrie G Lenneman, Oghenerukevwe Odiete, David B Friedman, Marvin W Kronenberg, Siyuen Zheng, Zhongming Zhao, Yanna Song, Frank E Harrell, Maya Srinivas, Anindita Ganguly, Jennifer Iaci, Tom J Parry, Anthony O Caggiano, Douglas B Sawyer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3578842?pdf=render

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