Low 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating viruses.

Low 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating viruses.

Influenza vaccine effectiveness (VE) is generally interpreted in the context of vaccine match/mismatch to circulating strains with evolutionary drift in the latter invoked to explain reduced protection. During the 2012-13 season, however, detailed genotypic and phenotypic characterization shows that...

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Bibliographic Details
Main Authors: Danuta M Skowronski, Naveed Z Janjua, Gaston De Serres, Suzana Sabaiduc, Alireza Eshaghi, James A Dickinson, Kevin Fonseca, Anne-Luise Winter, Jonathan B Gubbay, Mel Krajden, Martin Petric, Hugues Charest, Nathalie Bastien, Trijntje L Kwindt, Salaheddin M Mahmud, Paul Van Caeseele, Yan Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3965421?pdf=render

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http://europepmc.org/articles/PMC3965421?pdf=render

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