Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima

Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima

Most transcription factors (TFs) can bind to a population of sequences closely related to a single optimal site. However, some TFs can bind to two distinct sequences that represent two local optima in the Gibbs free energy of binding (ΔG). To determine the molecular mechanism behind this effect, we...

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Bibliographic Details
Main Authors: Ekaterina Morgunova, Yimeng Yin, Pratyush K Das, Arttu Jolma, Fangjie Zhu, Alexander Popov, You Xu, Lennart Nilsson, Jussi Taipale
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-04-01
Series:eLife
Subjects:
transcription factors
DNA recognition
thermodynamics
enthalpy
entropy
epistasis
Online Access:https://elifesciences.org/articles/32963

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