Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
Tumour associated macrophages (TAMs) have an altered lipid metabolism. Here the authors show that downregulation of monoacylglycerols lipase MGLL in TAMs induces lipid accumulation and tumor progression by polarizing TAMs toward tumor-promoting through activation of cannabinoid receptor CB2.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04999-8 |
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doaj-6eb51a074121441cbb4d93d358b47fe62021-05-11T09:26:26ZengNature Publishing GroupNature Communications2041-17232018-07-019111310.1038/s41467-018-04999-8Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progressionWei Xiang0Rongchen Shi1Xia Kang2Xuan Zhang3Peng Chen4Lili Zhang5Along Hou6Rui Wang7Yuanyin Zhao8Kun Zhao9Yingzhe Liu10Yue Ma11Huan Luo12Shenglan Shang13Jinyu Zhang14Fengtian He15Songtao Yu16Lixia Gan17Chunmeng Shi18Yongsheng Li19Wei Yang20Houjie Liang21Hongming Miao22Department of Biochemistry and Molecular Biology, Third Military Medical UniversityDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityDepartment of Oncology, Southwest Hospital, Third Military Medical UniversityDepartment of General Surgery, PLA 324 HospitalDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityNational Engineering Research Center of Immunological Products, Third Military Medical UniversityDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityDepartment of Oncology, Southwest Hospital, Third Military Medical UniversityDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityInstitute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical UniversityClinical Medicine Research Center & Institute of Cancer, Xinqiao Hospital, Third Military Medical UniversityDepartment of Pathology, School of Basic Medical Sciences & Nanfang Hospital, Southern Medical UniversityDepartment of Oncology, Southwest Hospital, Third Military Medical UniversityDepartment of Biochemistry and Molecular Biology, Third Military Medical UniversityTumour associated macrophages (TAMs) have an altered lipid metabolism. Here the authors show that downregulation of monoacylglycerols lipase MGLL in TAMs induces lipid accumulation and tumor progression by polarizing TAMs toward tumor-promoting through activation of cannabinoid receptor CB2.https://doi.org/10.1038/s41467-018-04999-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Wei Xiang Rongchen Shi Xia Kang Xuan Zhang Peng Chen Lili Zhang Along Hou Rui Wang Yuanyin Zhao Kun Zhao Yingzhe Liu Yue Ma Huan Luo Shenglan Shang Jinyu Zhang Fengtian He Songtao Yu Lixia Gan Chunmeng Shi Yongsheng Li Wei Yang Houjie Liang Hongming Miao |
| spellingShingle |
Wei Xiang Rongchen Shi Xia Kang Xuan Zhang Peng Chen Lili Zhang Along Hou Rui Wang Yuanyin Zhao Kun Zhao Yingzhe Liu Yue Ma Huan Luo Shenglan Shang Jinyu Zhang Fengtian He Songtao Yu Lixia Gan Chunmeng Shi Yongsheng Li Wei Yang Houjie Liang Hongming Miao Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression Nature Communications |
| author_facet |
Wei Xiang Rongchen Shi Xia Kang Xuan Zhang Peng Chen Lili Zhang Along Hou Rui Wang Yuanyin Zhao Kun Zhao Yingzhe Liu Yue Ma Huan Luo Shenglan Shang Jinyu Zhang Fengtian He Songtao Yu Lixia Gan Chunmeng Shi Yongsheng Li Wei Yang Houjie Liang Hongming Miao |
| author_sort |
Wei Xiang |
| title |
Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression |
| title_short |
Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression |
| title_full |
Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression |
| title_fullStr |
Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression |
| title_full_unstemmed |
Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression |
| title_sort |
monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-07-01 |
| description |
Tumour associated macrophages (TAMs) have an altered lipid metabolism. Here the authors show that downregulation of monoacylglycerols lipase MGLL in TAMs induces lipid accumulation and tumor progression by polarizing TAMs toward tumor-promoting through activation of cannabinoid receptor CB2. |
| url |
https://doi.org/10.1038/s41467-018-04999-8 |
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