Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
Tumour associated macrophages (TAMs) have an altered lipid metabolism. Here the authors show that downregulation of monoacylglycerols lipase MGLL in TAMs induces lipid accumulation and tumor progression by polarizing TAMs toward tumor-promoting through activation of cannabinoid receptor CB2.
Bibliographic Details
| Main Authors: |
Wei Xiang,
Rongchen Shi,
Xia Kang,
Xuan Zhang,
Peng Chen,
Lili Zhang,
Along Hou,
Rui Wang,
Yuanyin Zhao,
Kun Zhao,
Yingzhe Liu,
Yue Ma,
Huan Luo,
Shenglan Shang,
Jinyu Zhang,
Fengtian He,
Songtao Yu,
Lixia Gan,
Chunmeng Shi,
Yongsheng Li,
Wei Yang,
Houjie Liang,
Hongming Miao |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-04999-8
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