Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells.

Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells.

Cytolytic CD4 T cells (CD4 CTL) have been identified in vivo in response to viral infections; however, the factors necessary for driving the cytolytic phenotype have not been fully elucidated. Our previously published work suggests IL-2 may be the master regulator of perforin-mediated cytotoxicity i...

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Bibliographic Details
Main Authors: Aspen M Workman, Ashley K Jacobs, Alexander J Vogel, Shirley Condon, Deborah M Brown
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3930678?pdf=render

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