The IL-8 protease SpyCEP is detrimental for Group A Streptococcus host-cells interaction and biofilm formation

The IL-8 protease SpyCEP is detrimental for Group A Streptococcus host-cells interaction and biofilm formation

SpyCEP-mediated chemokine degradation translates into more efficient spreading and increased severity of invasive Group A Streptococcus (GAS) infections, due to impaired neutrophil recruitment to the site of infection. SpyCEP is markedly up-regulated in invasive as compared to colonizing GAS isolate...

Full description

Bibliographic Details
Main Authors: Federica eAndreoni, Taiji eOgawa, Mariko eOgawa, Jerzy eMadon, Satoshi eUchiyama, Reto Andreas Schuepbach, Annelies Sophie Zinkernagel
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Microbiology
Subjects:
Biofilms
Virulence Factors
colonization
group A streptococcus
SpyCEP
IL-8 protease
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00339/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00339/full

Similar Items