Synthesis and antimicrobial, antifungal and anthelmintic activities of 3H-1,5-benzodiazepine derivatives

• Main Authors: RAJESH KUMAR, Y. C. JOSHI
• Format: Article
• Language: English
• Published: Serbian Chemical Society 2008-10-01
• Series: Journal of the Serbian Chemical Society
• Subjects: 1; 5-benzodiazepines; β-diketones/β-ketoesters; substituted pyrazole; p-toluenesulfonic acid
• Online Access: http://www.shd.org.rs/JSCS/Vol73/No10/JSCS-3774.pdf

The diazonium salt of 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide in the presence of sodium hydroxide was condensed with different β-diketones/β-ketoesters, 3a–e, to obtain new β-diketones/β-ketoesters, 4a–e. The β-diketones/β-ketoesters 4a–e were condensed with o-phenylenediamine (o-PDA) in presence of p-toluenesulfonic acid/SiO2 to give biologically active 3H-1,5-benzodiazepines, 5a–e. All the newly synthesized compounds were characterized by elemental analysis and spectral studies. The compounds 5a–e was screened for their antimicrobial, antifungal and anthelmintic activities.