Optimization of Atropine Extraction Process from Atropa Belladonna by Modified Bubble Column Extractor with Ultrasonic Bath

• Main Authors: Akbar Abbaspour, Parissa Khadiv Parsi, Farahnaz Khalighi-Sigaroodi, Reza Ghaffarzadegan
• Format: Article
• Language: English
• Published: Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR 2016-12-01
• Series: Iranian Journal of Chemistry & Chemical Engineering
• Subjects: atropine; bubble column extraction; uniform design; uv-visible spectroscopy; atropa belladonna
• Online Access: http://www.ijcce.ac.ir/article_23556_c8658b3ac0ad7008631b8e029ae03d22.pdf

Modified Bubble Column Extraction with Ultrasonic Bath (BCE-UB) method was used to extract atropine from the stem and leaves of Atropa belladonna. Optimum condition were obtained with Kamada solvent which was chloroform-methanol-ammonia 15:15:1(v/v/v) as extraction solvent, the particle size of  less than  350 µm, an extraction time of 23.95 min, a liquor to material ratio of 15.08 mL/g and  an  air  flow of  6.31 mL/min.g. In this state, percent of extracted atropine was calculated which was equal to 6.81%. Percent of extracted atropine was 6.31% that showed a little difference compared to the predicted value. In order to study the effect of bubbles on the extraction rate, the same extraction with the previous method was performed in a stirred tank. Percent of atropine was 5.59%.