Neonatal Autopsies with Heart Disease: A Challenge for Pathologist
Congenital Heart Diseases (CHD) carry significant morbidity and mortality in paediatric patients. Transposition of Great Arteries (TGA) is a common cyanotic CHD. However, onset of Pulmonary Arterial Hypertension (PAH) is potentially severe and rare complication reported in 1-3% of newborns. Hypert...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2020-08-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/13960/44882_CE[Ra1]_F(SL)_PF1(AB_SL)_PN(SL).pdf |
Summary: | Congenital Heart Diseases (CHD) carry significant morbidity and mortality in paediatric patients. Transposition of Great Arteries
(TGA) is a common cyanotic CHD. However, onset of Pulmonary Arterial Hypertension (PAH) is potentially severe and rare
complication reported in 1-3% of newborns. Hypertrophic Cardiomyopathy (HOCM) is a primary disease of cardiac muscle usually
recognised in adulthood. Neonatal HOCM without other congenital anomalies, no family history of HOCM, no history of exposure
to corticosteroids or any inborn errors of metabolism is rarely recognised. Authors hereby report two cases of neonatal autopsy
showing TGA with PAH (Grade 2) and another with HOCM without any primary cause received in our hospital. With this case report
authors wish to stress on the importance of cardiac examination (heart and the associated vessels) in autopsy specimen which in
turn requires training of pathologists in cardiac pathology along with routine fetal anomaly scanning in arriving successively at the
final diagnosis and detecting the cause of death which helps in management of future pregnancies by the clinicians. |
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ISSN: | 2249-782X 0973-709X |