Graded doses of grape seed methanol extract attenuated hepato-toxicity following chronic carbamazepine treatment in male Wistar rats

Graded doses of grape seed methanol extract attenuated hepato-toxicity following chronic carbamazepine treatment in male Wistar rats

Aim: This study investigated the effects of co-administration of carbamazepine (CBZ) with grape (Vitis vinifera) seed methanolic extract (GSME) on liver toxicity. Method: Thirty-five male rats (145−155 g) were randomized into 5 groups (n = 7) and administered with propylene glycol (PG 0.1 mL/day), C...

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Bibliographic Details
Main Authors: Opeyemi Samson Osuntokun, Gbola Olayiwola, Tope Gafar Atere, Kabiru Isola Adedokun, Olayemi Olutobi Oladokun
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Toxicology Reports
Subjects:
Antiepileptic-drugs
Carbamazepine
Grape seed methanolic extract
Hepatotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750020304376

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