Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive System

Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive System

Bisphenol A (BPA) is a widespread chemical agent which can exert detrimental effects on the male reproductive system. Exposure to BPA has been shown to induce several epigenetic modifications in both animal and human cells. Specifically, BPA could not only modify the methylation pattern of multiple...

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Main Authors: Federica Cariati, Luigi Carbone, Alessandro Conforti, Francesca Bagnulo, Stefania Ramona Peluso, Consolata Carotenuto, Cira Buonfantino, Erminia Alviggi, Carlo Alviggi, Ida Strina
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Endocrinology
Subjects:
bisphenol A
male reproduction
infertility
epigenetic
oxidative stress
DNA methylation
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00453/full
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spelling doaj-6e844432ec8d4bb49db43458c8e4d1a42020-11-25T03:49:26ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-07-011110.3389/fendo.2020.00453544682Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive SystemFederica Cariati0Federica Cariati1Luigi Carbone2Alessandro Conforti3Francesca Bagnulo4Stefania Ramona Peluso5Consolata Carotenuto6Cira Buonfantino7Erminia Alviggi8Carlo Alviggi9Carlo Alviggi10Carlo Alviggi11Ida Strina12Ida Strina13CEINGE-Biotecnologie Avanzate s.c.a.r.l., Naples, ItalyFertility Unit, Maternal-Child Department, AOU Policlinico Federico II, Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University, Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University, Naples, ItalyFertility Unit, Maternal-Child Department, AOU Policlinico Federico II, Naples, ItalyFertility Unit, Maternal-Child Department, AOU Policlinico Federico II, Naples, ItalyMolecular Medicine and Medical Biotechnology Department, Federico II University, Naples, ItalyDepartment of Public Health, Federico II University, Naples, ItalyGENERA Centers for Reproductive Medicine, Clinica Ruesch, Naples, ItalyFertility Unit, Maternal-Child Department, AOU Policlinico Federico II, Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University, Naples, ItalyEndocrinology and Experimental Oncology Institute (IEOS), National Research Council, Naples, ItalyFertility Unit, Maternal-Child Department, AOU Policlinico Federico II, Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University, Naples, ItalyBisphenol A (BPA) is a widespread chemical agent which can exert detrimental effects on the male reproductive system. Exposure to BPA has been shown to induce several epigenetic modifications in both animal and human cells. Specifically, BPA could not only modify the methylation pattern of multiple genes encoding proteins related to reproductive physiology but also directly influence the genes responsible for DNA methylation. BPA effects include hormonal alterations, microscopic and macroscopic alteration of male reproductive organs, and inheritable epigenetic changes involving human reproduction. BPA exposure was also linked to prostate cancer. This review aims to show the current scenario of BPA-induced epigenetic changes and its effects on the male reproductive system. Possible strategies to counter the toxic effect of BPA were also addressed.https://www.frontiersin.org/article/10.3389/fendo.2020.00453/fullbisphenol Amale reproductioninfertilityepigeneticoxidative stressDNA methylation
collection DOAJ
language English
format Article
sources DOAJ
author Federica Cariati
Federica Cariati
Luigi Carbone
Alessandro Conforti
Francesca Bagnulo
Stefania Ramona Peluso
Consolata Carotenuto
Cira Buonfantino
Erminia Alviggi
Carlo Alviggi
Carlo Alviggi
Carlo Alviggi
Ida Strina
Ida Strina
spellingShingle Federica Cariati
Federica Cariati
Luigi Carbone
Alessandro Conforti
Francesca Bagnulo
Stefania Ramona Peluso
Consolata Carotenuto
Cira Buonfantino
Erminia Alviggi
Carlo Alviggi
Carlo Alviggi
Carlo Alviggi
Ida Strina
Ida Strina
Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive System
Frontiers in Endocrinology
bisphenol A
male reproduction
infertility
epigenetic
oxidative stress
DNA methylation
author_facet Federica Cariati
Federica Cariati
Luigi Carbone
Alessandro Conforti
Francesca Bagnulo
Stefania Ramona Peluso
Consolata Carotenuto
Cira Buonfantino
Erminia Alviggi
Carlo Alviggi
Carlo Alviggi
Carlo Alviggi
Ida Strina
Ida Strina
author_sort Federica Cariati
title Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive System
title_short Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive System
title_full Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive System
title_fullStr Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive System
title_full_unstemmed Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive System
title_sort bisphenol a-induced epigenetic changes and its effects on the male reproductive system
publisher Frontiers Media S.A.
series Frontiers in Endocrinology
issn 1664-2392
publishDate 2020-07-01
description Bisphenol A (BPA) is a widespread chemical agent which can exert detrimental effects on the male reproductive system. Exposure to BPA has been shown to induce several epigenetic modifications in both animal and human cells. Specifically, BPA could not only modify the methylation pattern of multiple genes encoding proteins related to reproductive physiology but also directly influence the genes responsible for DNA methylation. BPA effects include hormonal alterations, microscopic and macroscopic alteration of male reproductive organs, and inheritable epigenetic changes involving human reproduction. BPA exposure was also linked to prostate cancer. This review aims to show the current scenario of BPA-induced epigenetic changes and its effects on the male reproductive system. Possible strategies to counter the toxic effect of BPA were also addressed.
topic bisphenol A
male reproduction
infertility
epigenetic
oxidative stress
DNA methylation
url https://www.frontiersin.org/article/10.3389/fendo.2020.00453/full
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