Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
The pathogenesis of Streptococcus pyogenes (GAS) causing scarlet fever has been associated with the presence of prophages, such as ΦHKU.vir, and their products. Here, the authors characterize the exotoxins SpeC and Spd1 of ΦHKU.vir and show these to act synergistically to facilitate nasopharyngeal c...
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Nature Publishing Group
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18700-5 |
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doaj-6e79b1f03e764489835c1a7815d1f4042021-10-10T11:47:52ZengNature Publishing GroupNature Communications2041-17232020-10-0111111110.1038/s41467-020-18700-5Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenesStephan Brouwer0Timothy C. Barnett1Diane Ly2Katherine J. Kasper3David M. P. De Oliveira4Tania Rivera-Hernandez5Amanda J. Cork6Liam McIntyre7Magnus G. Jespersen8Johanna Richter9Benjamin L. Schulz10Gordon Dougan11Victor Nizet12Kwok-Yung Yuen13Yuanhai You14John K. McCormick15Martina L. Sanderson-Smith16Mark R. Davies17Mark J. Walker18Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of QueenslandAustralian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of QueenslandIllawarra Health and Medical Research InstituteDepartment of Microbiology and Immunology and the Centre for Human Immunology, Schulich School of Medicine & Dentistry, Western UniversityAustralian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of QueenslandAustralian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of QueenslandAustralian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of QueenslandDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of MelbourneDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of MelbourneAustralian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of QueenslandAustralian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of QueenslandThe Wellcome Trust Sanger InstituteDepartment of Pediatrics, University of California San DiegoState Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative RegionState Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Centre for Disease Control and PreventionDepartment of Microbiology and Immunology and the Centre for Human Immunology, Schulich School of Medicine & Dentistry, Western UniversityIllawarra Health and Medical Research InstituteAustralian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of QueenslandAustralian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of QueenslandThe pathogenesis of Streptococcus pyogenes (GAS) causing scarlet fever has been associated with the presence of prophages, such as ΦHKU.vir, and their products. Here, the authors characterize the exotoxins SpeC and Spd1 of ΦHKU.vir and show these to act synergistically to facilitate nasopharyngeal colonization in mice.https://doi.org/10.1038/s41467-020-18700-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Stephan Brouwer Timothy C. Barnett Diane Ly Katherine J. Kasper David M. P. De Oliveira Tania Rivera-Hernandez Amanda J. Cork Liam McIntyre Magnus G. Jespersen Johanna Richter Benjamin L. Schulz Gordon Dougan Victor Nizet Kwok-Yung Yuen Yuanhai You John K. McCormick Martina L. Sanderson-Smith Mark R. Davies Mark J. Walker |
| spellingShingle |
Stephan Brouwer Timothy C. Barnett Diane Ly Katherine J. Kasper David M. P. De Oliveira Tania Rivera-Hernandez Amanda J. Cork Liam McIntyre Magnus G. Jespersen Johanna Richter Benjamin L. Schulz Gordon Dougan Victor Nizet Kwok-Yung Yuen Yuanhai You John K. McCormick Martina L. Sanderson-Smith Mark R. Davies Mark J. Walker Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes Nature Communications |
| author_facet |
Stephan Brouwer Timothy C. Barnett Diane Ly Katherine J. Kasper David M. P. De Oliveira Tania Rivera-Hernandez Amanda J. Cork Liam McIntyre Magnus G. Jespersen Johanna Richter Benjamin L. Schulz Gordon Dougan Victor Nizet Kwok-Yung Yuen Yuanhai You John K. McCormick Martina L. Sanderson-Smith Mark R. Davies Mark J. Walker |
| author_sort |
Stephan Brouwer |
| title |
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes |
| title_short |
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes |
| title_full |
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes |
| title_fullStr |
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes |
| title_full_unstemmed |
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes |
| title_sort |
prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing streptococcus pyogenes |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-10-01 |
| description |
The pathogenesis of Streptococcus pyogenes (GAS) causing scarlet fever has been associated with the presence of prophages, such as ΦHKU.vir, and their products. Here, the authors characterize the exotoxins SpeC and Spd1 of ΦHKU.vir and show these to act synergistically to facilitate nasopharyngeal colonization in mice. |
| url |
https://doi.org/10.1038/s41467-020-18700-5 |
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