Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas.

Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas.

Diffuse intrinsic pontine glioma (DIPG) is one of the most frequent malignant pediatric brain tumor and its prognosis is universaly fatal. No significant improvement has been made in last thirty years over the standard treatment with radiotherapy. To address the paucity of understanding of DIPGs, we...

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Bibliographic Details
Main Authors: Stephanie Puget, Cathy Philippe, Dorine A Bax, Bastien Job, Pascale Varlet, Marie-Pierre Junier, Felipe Andreiuolo, Dina Carvalho, Ricardo Reis, Lea Guerrini-Rousseau, Thomas Roujeau, Philippe Dessen, Catherine Richon, Vladimir Lazar, Gwenael Le Teuff, Christian Sainte-Rose, Birgit Geoerger, Gilles Vassal, Chris Jones, Jacques Grill
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3289615?pdf=render

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