Whole genome sequencing analysis identifies recurrent structural alterations in esophageal squamous cell carcinoma

Whole genome sequencing analysis identifies recurrent structural alterations in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is the predominant type of esophageal cancer in the Asian region, including Japan. A previous study reported mutational landscape of Japanese ESCCs by using exome sequencing. However, somatic structural alterations were yet to be explored. To provide a compr...

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Bibliographic Details
Main Authors: Munmee Dutta, Hidewaki Nakagawa, Hiroaki Kato, Kazuhiro Maejima, Shota Sasagawa, Kaoru Nakano, Aya Sasaki-Oku, Akihiro Fujimoto, Raúl Nicolás Mateos, Ashwini Patil, Hiroko Tanaka, Satoru Miyano, Takushi Yasuda, Kenta Nakai, Masashi Fujita
Format: Article
Language:English
Published: PeerJ Inc. 2020-06-01
Series:PeerJ
Subjects:
Esophageal squamous cell carcinoma
Whole genome sequencing
Coding mutation
Mutational signature
Structural variation
Copy number alteration
Online Access:https://peerj.com/articles/9294.pdf

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