Aflatoxin B1 up-regulates insulin receptor substrate 2 and stimulates hepatoma cell migration.

Aflatoxin B1 up-regulates insulin receptor substrate 2 and stimulates hepatoma cell migration.

Aflatoxin B1 (AFB1) is a potent carcinogen that can induce hepatocellular carcinoma. AFB1-8,9-exo-epoxide, one of AFB1 metabolites, acts as a mutagen to react with DNA and induce gene mutations, including the tumor suppressor p53. In addition, AFB1 reportedly stimulates IGF receptor activation. Aber...

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Bibliographic Details
Main Authors: Yanli Ma, Qingbin Kong, Hui Hua, Ting Luo, Yangfu Jiang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3480444?pdf=render

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