PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway

PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway

Abstract Background Glucocorticoid (GC)-associated osteonecrosis of the femoral head (ONFH) is the most common in non-traumatic ONFH. Despite a strong relationship between GC and ONFH, the detailed mechanisms have remained elusive. Recent studies have shown that GC could directly injure the blood ve...

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Bibliographic Details
Main Authors: Xudong Yao, Shengnan Yu, Xingzhi Jing, Jiachao Guo, Kai Sun, Fengjing Guo, Yaping Ye
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Stem Cell Research & Therapy
Subjects:
Glucocorticoid-associated osteonecrosis of the femoral head
Endothelial progenitor cells
Angiogenesis
Apoptosis
Nrf2
Online Access:http://link.springer.com/article/10.1186/s13287-020-01658-y

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