Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition

Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition

Abstract Background Pulmonary fibrosis is a late manifestation of acute respiratory distress syndrome (ARDS). Sepsis is a major cause of ARDS, and its pathogenesis includes endotoxin-induced vascular injury. Recently, endothelial-to-mesenchymal transition (EndMT) was shown to play an important role...

Full description

Bibliographic Details
Main Authors: Toshio Suzuki, Yuji Tada, Santhi Gladson, Rintaro Nishimura, Iwao Shimomura, Satoshi Karasawa, Koichiro Tatsumi, James West
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Respiratory Research
Subjects:
Endothelial-to-mesenchymal transition
Pulmonary fibrosis
Dipeptidyl peptidase 4
Post ARDS pulmonary fibrosis
Online Access:http://link.springer.com/article/10.1186/s12931-017-0660-4

Similar Items

Similar Items