HA antibody mediated FcγRIIIa activity is both dependent on FcR engagement and interactions between HA and sialic acids

HA antibody mediated FcγRIIIa activity is both dependent on FcR engagement and interactions between HA and sialic acids

Interactions with receptors for the Fc region of IgG (FcγRs) have been shown to contribute to the in vivo protection against influenza A viruses provided by broadly neutralizing antibodies (bnAbs) that bind to the viral hemagglutinin (HA) stem. In particular, Fc-mediated antibody-dependent cellular...

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Bibliographic Details
Main Author: Freek Cox
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Immunology
Subjects:
Sialic Acids
ADCC
HAI
stem-binder
head-binder
CR9114
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00399/full

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