Human COMT over-expression confers a heightened susceptibility to dyskinesia in mice

Human COMT over-expression confers a heightened susceptibility to dyskinesia in mice

Catechol-O-methyltransferase (COMT) degrades dopamine and its precursor l-DOPA and plays a critical role in regulating synaptic dopamine actions. We investigated the effects of heightened levels of COMT on dopamine-regulated motor behaviors and molecular alterations in a mouse model of dyskinesia. T...

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Bibliographic Details
Main Authors: Oscar Solís, Jose-Rubén García-Montes, Patricia Garcia-Sanz, Antonio S. Herranz, Maria-José Asensio, Gina Kang, Noboru Hiroi, Rosario Moratalla
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Neurobiology of Disease
Subjects:
l-DOPA
LID
Abnormal involuntary movements
TXNRD2
COMT
ARVCF
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117300542

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