Blastoid Variant of Mantle Cell Lymphoma with Leukemic Presentation - A Rare Case Report

• Main Authors: Ruchee Khanna, Sushma Belurkar, P. Lavanya, Chethan Manohar, Manna Valiathan
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2017-04-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: flow cytometry; hepatomegaly; non-hodgkin's lymphoma
• Online Access: https://jcdr.net/articles/PDF/9670/24221_CE[Ra1]_F(DK)_PF1_(PB_PY)_PFA(RB_PY).pdf
• ISSN: 2249-782X; 0973-709X

Mantle Cell Lymphoma (MCL) is a type of Non-Hodgkin's lymphoma and has a wide spectrum of histopathological subtypes of which the blastoid or the blastic variant constitutes 10-15% of all cases. It is difficult to diagnose blastoid variant of MCL on the basis of morphology alone as it mimics lymphoblastic lymphoma and centroblastic large cell lymphoma, hence additional analysis like immunophenotyping and molecular studies aid in its diagnosis. We present a case of 45-year-old male who presented to medicine OPD with chief complaints of fever, fatigability and inguinal swelling. Complete blood count, peripheral smear and bone marrow examination was performed. Peripheral smear showed thrombocytopenia along with 53% abnormal cells. On bone marrow examination 43% abnormal lymphoid cells were seen. This case was diagnosed as blastoid variant of MCL on the basis of routine morphology and immunohistochemistry on bone marrow biopsy and flow cytometric immunophenotyping on peripheral blood.